Chlorendic anhydride
CAS No.: 115-27-5 Formula: C9H2Cl6O3 Molecular Weight: 370.82800
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Chlorendic anhydride

CAS No.: 115-27-5 Formula: C9H2Cl6O3 Molecular Weight: 370.82800
Suppliers: All (104) China Suppliers (59) Price Available (12) Contractor (4)

Basic Info

Chemical Name
Chlorendic anhydride
Molecular Formula
Molecular Weight

Numbering system

MDL number
PubChem number
EINECS number
BRN number
RTECS number


Appearance & Physical State
white crystalline powder or chunks
1.99 g/cm3
Boiling Point
466ºC at 760 mmHg
Melting Point
Flash Point
Refractive Index
Water Solubility
Vapor Density
13 (vs air)

Safety Info

Safety Statements
HS Code
WGK Germany
UN 1759
Risk Statements
R36/37/38; R45; R51/53
Hazard Codes
T; N
Hazard Declaration
H315; H319; H335; H351; H373; H412
GHS07, GHS08
Signal Word
Caution Statement
P273; P305 + P351 + P338
SDS 1.0 Expand

SDS 1.0

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According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name
Chlorendic anhydride

1.2 Other means of identification

Product number
Other names
Chlorendic anhydride

1.3 Recommended use of the chemical and restrictions on use

Identified uses
For industry use only. Flame retardants
Uses advised against
no data available

1.4 Supplier's details

MOLBASE (Shanghai) Biotechnology Co., Ltd.
Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China

1.5 Emergency phone number

Emergency phone number
Service hours
Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity – single exposure, Category 3

2.2 GHS label elements, including precautionary statements

Signal word


Hazard statement(s)

H315 Causes skin irritation

H319 Causes serious eye irritation

H335 May cause respiratory irritation

Precautionary statement(s)

P264 Wash ... thoroughly after handling.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.


P302+P352 IF ON SKIN: Wash with plenty of water/...

P321 Specific treatment (see ... on this label).

P332+P313 If skin irritation occurs: Get medical advice/attention.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P337+P313 If eye irritation persists: Get medical advice/attention.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P312 Call a POISON CENTER/doctor/…if you feel unwell.


P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.


P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification


3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
Chlorendic anhydride
Chlorendic anhydride

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Half-upright position. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Do NOT induce vomiting.

4.2 Most important symptoms/effects, acute and delayed

no data available

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Absorption, Distribution and Excretion

The pharmacokinetics of chlorendic anhydride was evaluated in 4 male and 8 female Holzman's albino rats that ingested 14C-chlorendic anhydride via gavage in a single dose of 3.65 (Group 1: 2 females), 4.00 (Group 2: 4 females), 5.55 (Group 3: 2 females) or 3.62 mg/kg (Group 4: 4 males). Blood was drawn from females treated with 4 mg/kg at 1, 4, 8, 17, 24, 48, 72 and 96 hr after dosing. Urine and feces were collected daily in the Group 1, 3 and 4 rats. Animals were sacrificed 17, 96, 192 and 192 hr, respectively, after treatment, and selected tissues were excised. Regardless of sex, the primary route of excretion was the feces, 70% of the administered dose being eliminated within the first 72 hr. Only 10% of the administered dose was eliminated in the urine. After 192 hr, the maximum residues present in any tissue were <0.1 mg/kg, with the exception of the fat (0.121 mg/kg) and liver (0.296 mg/kg). The blood concentration of chlorendic anhydride peaked 1 hr after dosing and was significantly decreased by 96 hr. The absorption of chlorendic anhydride followed the two-compartment open model. The first compartment was suggested to consist of the blood and selected tissues which equilibrated rapidly, while the second compartment consisted of the fat which was slow in equilibrating and considered a deep reservoir.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

In case of fire in the surroundings, use appropriate extinguishing media.

5.2 Specific hazards arising from the chemical

no data available

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.

6.3 Methods and materials for containment and cleaning up

Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. (Extra personal protection: P2 filter respirator for harmful particles.)

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Dry. Well closed.Dry. Well closed.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state
white crystalline powder or chunks
Fine white crystals
no data available
Melting point/ freezing point
Boiling point or initial boiling point and boiling range
Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit
no data available
Flash point
Auto-ignition temperature
no data available
Decomposition temperature
no data available
no data available
Kinematic viscosity
no data available
In water:insoluble
Partition coefficient n-octanol/water (log value)
log Kow = 4.4 /Estimated/
Vapour pressure
5.5X10-7 mm Hg @ 25°C /Estimated/
Density and/or relative density
1.99 g/cm3
Relative vapour density
13 (vs air)
Particle characteristics
no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

In aqueous solution, chlorendic anhydride is rapidly hydrolysed to chlorendic acid, with a half-life of approximately one hour.

10.3 Possibility of hazardous reactions


10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Chlorendic anhydride will react almost quantitatively with excess methanol to form monomethyl chlorendate

10.6 Hazardous decomposition products

When heated to decomposition it emits toxic fumes of /hydrogen chloride/.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Mouse oral 2400 mg/kg
  • Inhalation: LC50 Rat (albino) inhalation >5.27 mg/L/4 hr
  • Dermal: no data available
  • Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available


    no data available

    Reproductive toxicity

    no data available

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    12.Ecological information

    12.1 Toxicity

  • Toxicity to fish: LC50 Salmo gairdneri (Rainbow trout, mean length 44mm, mean weight 0.61 g, age 3 months) >1000 mg/L/24 hr; 947.6 mg/L/48 hr (95% confidence interval: 785-1144 mg/L); 422.7 mg/L/96 hr; static, pH 7.54, 10°C +/- 1°C, total alkalinity 28 mg/L and CaCO3, total hardness 42 mg/L as CaCO3, specific conductivity 145 umhos/cm /93.81% pure chlorendic anhydride
  • Toxicity to daphnia and other aquatic invertebrates: LC50 Daphnia magna (age <20 hr) 127.9 mg/L/24 hr (95% confidence interval: 118.1-138.4 mg/L); 110.7 mg/L/48 hr (95% confidence interval: 97.6-125.6 mg/L); static- nonrenewal, 17 +/- 2°C, pH 4.50-7.43, hardness 52 mg/L as CaCO3, alkalinity 29 mg/L CaCO3, specific conductivity 130 umhos/cm /93.81% pure chlorendic anhydride
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available
  • 12.2 Persistence and degradability

    no data available

    12.3 Bioaccumulative potential

    no data available

    12.4 Mobility in soil

    no data available

    12.5 Other adverse effects

    no data available

    13.Disposal considerations

    13.1 Disposal methods


    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    14.Transport information

    14.1 UN Number

    ADR/RID: Not dangerous goods.
    IMDG: Not dangerous goods.
    IATA: Not dangerous goods.

    14.2 UN Proper Shipping Name

    ADR/RID: unknown
    IMDG: unknown
    IATA: unknown

    14.3 Transport hazard class(es)

    ADR/RID: Not dangerous goods.
    IMDG: Not dangerous goods.
    IATA: Not dangerous goods.

    14.4 Packing group, if applicable

    ADR/RID: Not dangerous goods.
    IMDG: Not dangerous goods.
    IATA: Not dangerous goods.

    14.5 Environmental hazards

    ADR/RID: no
    IMDG: no
    IATA: no

    14.6 Special precautions for user

    no data available

    14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

    no data available

    15.Regulatory information

    15.1 Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    Chlorendic anhydride
    Chlorendic anhydride
    European Inventory of Existing Commercial Chemical Substances (EINECS)
    EC Inventory
    United States Toxic Substances Control Act (TSCA) Inventory
    China Catalog of Hazardous chemicals 2015
    Not Listed.
    New Zealand Inventory of Chemicals (NZIoC)
    Philippines Inventory of Chemicals and Chemical Substances (PICCS)
    Vietnam National Chemical Inventory
    Not Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)

    16.Other information

    Information on revision

    Creation Date
    Aug 10, 2017
    Revision Date
    Aug 10, 2017

    Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%
  • References

  • IPCS - The International Chemical Safety Cards (ICSC), website:
  • HSDB - Hazardous Substances Data Bank, website:
  • IARC - International Agency for Research on Cancer, website:
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:
  • CAMEO Chemicals, website:
  • ChemIDplus, website:
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website:
  • Germany GESTIS-database on hazard substance, website:
  • ECHA - European Chemicals Agency, website:

  • Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
    MSDS Expand
    1H NMR : PredictExpand

    NMR Spectrum 1H NMR : Predict

    Mass spectrum (electron ionization)Expand
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